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ADP-ribosylation at the nuclear pore complex

Our group focuses on two cellular processes that are often deregulated during aging and diseases:

  • Genome stability maintenance

  • Trafficking through the nuclear pore complex (NPC).

We address several outstanding questions regarding the posttranslational modifications (PTMs) that regulate NPC functions and the contribution of the individual NPC components to DNA repair, both within the NPC and outside of it. We are particularly interested in the contribution of ADP-ribosylation (ADPr) to nuclear pore complex (NPC) regulation through the biomedically important enzyme PARP1, an integrated early stress responder to DNA damage; and through PARP11, an elusive enzyme that specifically localizes to the nuclear periphery. We employ advanced proteomics technology as well as super resolution microscopy to identify the role of ADP-ribosylation at the NPCs.